This panel is useful for PI3K pathway research and for anti-cancer drug discovery.
Biosafety Level
2 [Cells contain Parainfluenza virus type 5]
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Comments
The Phosphoinositide 3?kinases (PI3Ks) family of enzymes is integral to several signaling pathways that mediate cell proliferation, survival, migration and vesicular trafficking. Member of the PI3K family are frequently mutated or altered in human cancers. For example, gain-of-function mutations in p110α (encoded by the PI3KCA gene) are observed in a variety of common cancers; and, these mutations are exclusively clustered in one of two hotspot regions, (i.e., exon 9 and 20), which correspond to either the helical or kinase domains of the protein (e.g., E545K and H1047R).
The PI3K Genetic Alteration Cell Panel (ATCC TCP-1028) is composed of ten human tumor cell lines from common cancer types that carry hotspot mutations within the PIK3CA gene. The PI3KCA status of each cell line has been sequenced and validated by ATCC. This panel is useful for PI3K pathway research and for anti-cancer drug discovery.
