| Comments |
The antibody reacts with vitronectin receptors on human polymorphonuclear leukocytes (PMN, neutrophils) and blocks the receptor binding to the tripeptide Arg-Gly-Asp (RGD).
The antibody also inhibits RGD stimulated phagocytosis.
It precipitates a heterodimer of apparent molecular weights 140000 and 105000 daltons.
The antibody does not react with gpIIb/III or the LFA-1/Mac-1 family of cellular adhesion receptors. |
| References |
Brown EJ. Novel monoclonal antibodies. US Patent 5,057,604 dated Oct 15 1991
Lindberg FP, et al. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J. Biol. Chem. 269: 1567-1570, 1994. PubMed: 8294396
Hay, R. J., Caputo, J. L., and Macy, M. L., Eds. (1992), ATCC Quality Control Methods for Cell Lines. 2nd edition, Published by ATCC.
Caputo, J. L., Biosafety procedures in cell culture. J. Tissue Culture Methods 11:223-227, 1988.
Fleming, D.O., Richardson, J. H., Tulis, J.J. and Vesley, D., (1995) Laboratory Safety: Principles and Practice. Second edition, ASM press, Washington, DC.
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