| 產品名稱 |
Dengue virus type 3 |
| 商品貨號 |
B161925 |
| Classification |
Flaviviridae, Flavivirus |
| Agent |
Dengue virus type 3 |
| Strain |
Monoclonal anti-Dengue virus type 3 E protein, clone E1 (produced in vitro) |
| Applications |
Emerging infectious disease research |
| Biosafety Level |
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Product Format |
frozen |
| Storage Conditions |
?-20°C or colder Repeated freeze-thaw cycles should be avoided |
| Comments |
Antibody Class: IgG2aκ The B cell hybridoma was generated by the fusion of P3X63.Ag.8.6.5.3 BALB/c mouse myeloma cells with immunized mouse splenocytes. The clone E1 antibody is reported to bind to domain III in the envelope glycoprotein. |
| Name of Depositor |
MS Diamond, Washington University in St. Louis, School of Medicine |
| Source |
Mouse monoclonal antibody prepared against the envelope glycoprotein of dengue virus type 3 was purified from clone E1 hybridoma supernatant by protein G affinity chromatography. |
| References |
Balsitis SJ, et al. Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. PLoS Pathog. 6: e1000790, 2012. PubMed: 20168989
Rajamanonmari R, et al. On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. J. Gen. Virol. 90: 799-809, 2009. PubMed: 19264660
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