converts: antitumor alkaloid acronycine to 9-hydroxyacronycine
Biosafety Level
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format
frozen
Storage Conditions
Frozen: -80°C or colder Freeze-Dried: 2°C to 8°C Live Culture: See Propagation Section
Type Strain
no
Preceptrol®
no
Medium
ATCC® Medium 336: Potato dextrose agar (PDA)
Growth Conditions
Temperature: 24.0°C
Name of Depositor
NRRL
Cross References
Nucleotide (GenBank) :
AF043517
Cunninghamella echinulata var. echinulata major nuclease C1A
Nucleotide (GenBank) :
AF109676
Cunninghamella echinulata var. echinulata minor nuclease C1B
References
Theriault RJ. Mycarosyl macrolide antibiotics. US Patent 3,784,447 dated Jan 8 1974
Betts RE, et al. Microbial transformations of antitumor compounds. I. Conversion of acronycine to 9-hydroxyacronycine by Cunninghamella echinulata. J. Med. Chem. 17: 599-602, 1974. PubMed: 4829940
Clark AM, Hufford CD. Microbial transformations of the sesquiterpene lactone costunolide. J. Chem. Soc. Perkin Trans. 1979: 3022-3028, 1979.
Chien MM, Rosazza JP. Microbial transformations of natural antitumor agents. 9. O-Demethylation of 9-methoxyellipticine. J. Nat. Prod. 42: 643-647, 1979. PubMed: 575547
