| Comments |
Restriction digests of the clone give the following sizes (kb): EcoRI--3.5, 2.35, 0.85, 0.4; NotI--4.8, 2.35; BamHI--3.8, 2.5, 0.9; SalI--4.3, 2.9; PvuI--1.95 (doublet), 1.6, 1.2, 0.5. The insert contains the following restriction sites (approximate kb from the 5' end): BamHI--1.26, 3.70; EcoRI--3.32, 3.68, 3.75; SalI--2.74. Encodes the X isoform (7.6 kb transcript). Contains the complete coding sequence (nt 713-4522). Corresponds exactly to GenBank accession L12374. |
| References |
Van de Ven WJ, et al. Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway. Enzyme 45: 257-270, 1991. PubMed: 1843280
Roebroek AJ, et al. Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene. EMBO J. 12: 1853-1870, 1993. PubMed: 8491178
Wim J Van De Ven, personal communication
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